Proteasome Subunit Beta Type-5

Preferred Label : Proteasome Subunit Beta Type-5;

NCIt synonyms : Macropain Epsilon Chain; Proteasome Chain 6; Proteasome Subunit MB1; Proteasome Epsilon Chain; Multicatalytic Endopeptidase Complex Epsilon Chain; Proteasome Beta 5 Subunit; Proteasome Subunit X; Proteasome Subunit Beta-5; EC 3.4.25.1; PSX Large Multifunctional Protease X; Proteasome Catalytic Subunit 3; B5 Proteasome Subunit; PSMB5;

NCIt definition : Proteasome subunit beta type-5 (263 aa, 28 kDa) is encoded by the human PSMB5 gene. This protein plays a role in proteasomal protein degradation.;

NCIt note : Proteasome subunit beta type-5 is responsible of the chymotrypsin-like activity of the proteasome and is one of targets for the proteasome inhibitor bortezomib. (UniProt) Proteasome subunit beta type-5 can be displaced by the equivalent immune-specific subunit PSMB8. (UniProt);

Details

Origin ID

C116677;

UMLS CUI

C1313038;

Automatic exact mappings (from CISMeF team)
- Proteasome subunit, beta-type, 5 [OMIM gene]
- proteasome 20S subunit beta 5 [HGNC gene]
OMIM relation
- Proteasome subunit, beta-type, 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PSMB5 protein, human [MeSH Supplementary Concept]
- PSMB5 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- PSMB5 Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Proteasome [NCIt concept]
gene_product_has_biochemical_function
- Endopeptidase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Proteasome Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Processing [NCIt concept]
- Apoptosis [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
is_target
- Carbon C 14-labeled Ixazomib [NCIt concept]
- Ixazomib [NCIt concept]
- Ixazomib Citrate [NCIt concept]

Keyword's position in hierarchy(ies) :

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