Proteasome - CISMeF

Preferred Label : Proteasome;

NCIt synonyms : Proteosome;

NCIt definition : Proteolytic complexes, proteolytic core of the proteasome system, that degrade cytosolic and nuclear proteins are implicated in ATP dependent ubiquitin protein complex degradation and in antigen processing in antigen presenting cells. The 20S proteasome (700 kD), essential in ATP ubiquitin degradation pathway, has 13-15 subunits each of which has three or four different peptidase activities. The 20S proteasome interacts with additional subunits, PA700 and PA28, to form an ATP-dependent multicatalytic proteinase complex (MPC) involved in the degradation of ubiquitinated cellular proteins and certain non-ubiquitinated proteins. 26S proteasomes may be formed in an ATP dependent fashion from a 20S proteasome and additional components, CF1 (660 kD), CF2 (250 kD) and CF3 (600 kD).;

NCI Metathesaurus CUI : CL448735;

Details

Origin ID

C13314;

UMLS CUI

C0208355;

Anatomic structure is physical part of
- Cell [NCIt concept]
Associated anatomy of gene products
- Proteasome Activator Complex Subunit 3 [NCIt concept]
- Proteasome Subunit Alpha Type-5 [NCIt concept]
- Proteasome Subunit Beta Type-10 [NCIt concept]
- Proteasome Subunit Beta Type-5 [NCIt concept]
- Proteasome Subunit Beta Type-8 [NCIt concept]
- Ubiquilin-4 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 14 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5 [NCIt concept]
Automatic exact mappings (from CISMeF team)
- Multicatalytic endopeptidase complex (substance) [SNOMED CT concept]
- obsolete proteasome endopeptidase activity [GO term]
- proteasome complex [GO term]
- proteasome endopeptidase complex [MeSH Descriptor]
- proteasome endopeptidase complex [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Multicatalytic endopeptidase complex (substance) [SNOMED CT concept]
- proteasome endopeptidase complex [MeSH concept]
- proteasome endopeptidase complex [MeSH Descriptor]
is_target
- Delanzomib [NCIt concept]
- Disulfiram [NCIt concept]

Keyword's position in hierarchy(ies) :

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