Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5

Preferred Label : Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5;

NCIt synonyms : EC 3.4.19.12; Ubiquitin Carboxyl-Terminal Esterase L5; Ubiquitin C-Terminal Hydrolase L5; Ubiquitin Thioesterase L5; UCHL5; Ubiquitin Carboxyl-Terminal Hydrolase L5; INO80 Complex Subunit R; Ubiquitin C-Terminal Hydrolase UCH37;

NCIt definition : Ubiquitin carboxyl-terminal hydrolase isozyme L5 (329 aa, 38 kDa) is encoded by the human UCHL5 gene. This protein plays a role in chromatin modification and the removal of lysine-48-linked polyubiquitin chains from substrate proteins.;

NCI Metathesaurus CUI : CL937993;

Details

Origin ID

C158570;

UMLS CUI

C1432066;

Automatic exact mappings (from CISMeF team)
- Ubiquitin carboxyl-terminal hydrolase l5 [OMIM gene]
- ubiquitin C-terminal hydrolase L5 [HGNC gene]
OMIM relation
- Ubiquitin carboxyl-terminal hydrolase l5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- UCHL5 protein, human [MeSH Supplementary Concept]
- UCHL5 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
- UCHL5 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
- Proteasome [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitin C-Terminal Hydrolase [NCIt concept]
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_physical_part_of
- INO80 Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Deubiquitination [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]
- Regulation of Proteolysis [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
is_target
- USP14/UCHL5 Inhibitor VLX1570 [NCIt concept]

Keyword's position in hierarchy(ies) :

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