Ubiquitin C-Terminal Hydrolase

Preferred Label : Ubiquitin C-Terminal Hydrolase;

NCIt synonyms : UCH; Ubiquitin Carboxyl-Terminal Hydrolase;

NCIt definition : The Ubiquitin C-Terminal Hydrolases (UCH) are deubiquitinating enzymes which hydrolyze carboxyl-terminal esters and amides of ubiquitin to generate free monomeric ubiquitin from ubiquitin proproteins, but not to deubiquitinate ubiquitin-protein conjugates or disassemble polyubiquitin chains. The expression of these enzymes is tissue-specific and developmentally regulated. Members of this deubiquitinating family are also important modulators of cellular function. (NCI);

Details

Origin ID

C21558;

UMLS CUI

C0164005;

Automatic exact mappings (from CISMeF team)
- thiol-dependent ubiquitinyl hydrolase activity [GO term]
- ubiquitin thiolesterase [MeSH concept]
- ubiquitin thiolesterase [MeSH Descriptor]
Biochemical function of gene products
- Ataxin-3 [NCIt concept]
- Probable Ubiquitin Carboxyl-Terminal Hydrolase FAF-X [NCIt concept]
- Probable Ubiquitin Carboxyl-Terminal Hydrolase FAF-Y [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 1 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 13 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 14 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 17 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 22 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 28 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 32 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 44 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 46 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 6 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 7 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 8 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase BAP1 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase CYLD [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5 [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Ubiquitin thiolesterase (substance) [SNOMED CT concept]
- ubiquitin thiolesterase [MeSH concept]
- ubiquitin thiolesterase [MeSH Descriptor]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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