Ubiquitin Carboxyl-Terminal Hydrolase 1

Preferred Label : Ubiquitin Carboxyl-Terminal Hydrolase 1;

NCIt synonyms : EC 3.4.19.12; Ubiquitin-Specific-Processing Protease 1; Ubiquitin Thioesterase 1; hUBP; USP1; Ubiquitin Specific Protease 1; Deubiquitinating Enzyme 1; Ubiquitin Specific Peptidase 1; Ubiquitin Thiolesterase 1; Ubiquitin Specific Processing Protease 1; Ubiquitin-Specific Protease 1;

NCIt definition : Ubiquitin carboxyl-terminal hydrolase 1 (785 aa, 88 kDa) is encoded by the human USP1 gene. This protein is involved in the deubiquitination of certain monoubiquitinated DNA repair proteins, including proliferating cell nuclear antigen (PCNA) and Fanconi anemia group D2 protein (FANCD2).;

Details

Origin ID

C185668;

UMLS CUI

C3711185;

Automatic exact mappings (from CISMeF team)
- Ubiquitin-specific protease 1 [OMIM gene]
- ubiquitin specific peptidase 1 [HGNC gene]
OMIM relation
- Ubiquitin-specific protease 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- USP1 protein, human [MeSH Supplementary Concept]
- USP1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
- USP1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitin C-Terminal Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair Inhibition [NCIt concept]
- Deubiquitination [NCIt concept]
- Hydrolysis [NCIt concept]
- Protein Cleavage [NCIt concept]
- Protein Degradation Inhibition [NCIt concept]
- Proteolysis [NCIt concept]
is_target
- USP1 Inhibitor ISM3091 [NCIt concept]
- USP1 Inhibitor TNG348 [NCIt concept]
- USP1 inhibitor KSQ-4279 [NCIt concept]

Keyword's position in hierarchy(ies) :

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