Preferred Label : USP1 Inhibitor TNG348;
NCIt definition : An orally bioavailable small molecule inhibitor of the human deubiquitinating enzyme
ubiquitin specific protease 1 (USP1), with potential antineoplastic activity. Upon
oral administration, USP1 inhibitor TNG348 specifically targets, allosterically binds
to and inhibits the activity of USP1, thereby blocking USP1-mediated deubiquitinating
activity. This may result in replication fork degradation, inhibition of DNA damage
repair, and decreased tumor cell survival. USP1, a deubiquitinating enzyme overexpressed
in various tumor cell types, plays a key role in the correct folding and deubiquitylation
of proteins and facilitates DNA repair via its role regulating the Fanconi anemia
complex and translesion synthesis. It plays a key role in the proliferation and survival
of homologous recombination deficient (HRD)-positive tumor cells.;
Molecule name : TNG 348; TNG-348;
NCI Metathesaurus CUI : CL1922702;
Origin ID : C203512;
UMLS CUI : C5908005;
Semantic type(s)
- concept_is_in_subset
- has_target
