Preferred Label : USP1 Inhibitor HSK39775;
NCIt synonyms : Ubiquitin Specific Protease 1 Inhibitor HSK39775;
NCIt definition : An orally bioavailable small molecule inhibitor of the human deubiquitinating enzyme
ubiquitin specific protease 1 (USP1; ubiquitin carboxyl-terminal hydrolase 1), with
potential antineoplastic activity. Upon oral administration, USP1 inhibitor HSK39775
specifically targets, binds to and inhibits the activity of USP1, thereby blocking
complex formation of USP1 with USP1-associated factor 1 (UAF1), and inhibits USP1-mediated
deubiquitinating activity. This may result in replication fork degradation, accumulation
of mono-ubiquinated substrates, inhibition of DNA damage repair, induction of cell
cycle arrest and apoptosis, and decreased survival of susceptible tumor cells. USP1,
overexpressed in various tumor cell types, plays a key role in the correct folding
and deubiquitylation of proteins and facilitates DNA repair via its role in regulating
the Fanconi anemia complex and translesion synthesis. It plays an important role in
the proliferation and survival of homologous repair deficiency (HRD)-positive tumor
cells.;
Molecule name : HSK 39775; HSK-39775;
Origin ID : C212051;
concept_is_in_subset
- has_target
