Preferred Label : USP1 Inhibitor ISM3091;
NCIt definition : An orally bioavailable small molecule inhibitor of the human deubiquitinating enzyme
ubiquitin specific protease 1 (USP1), with potential antineoplastic activity. Upon
oral administration, USP1 inhibitor ISM3091 specifically targets, binds to and inhibits
the activity of USP1, thereby blocking USP1-mediated deubiquitinating activity. This
may result in replication fork degradation, inhibition of DNA damage repair, and decreased
tumor cell survival. USP1, a deubiquitinating enzyme overexpressed in various tumor
cell types, plays a key role in the correct folding and deubiquitylation of proteins
and facilitates DNA repair via its role regulating the Fanconi anemia complex and
translesion synthesis.;
Molecule name : ISM 3091; ISM-3091;
NCI Metathesaurus CUI : CL1922626;
Origin ID : C203403;
UMLS CUI : C5908000;
Semantic type(s)
- concept_is_in_subset
- has_target
