Ubiquitin Carboxyl-Terminal Hydrolase 8

Preferred Label : Ubiquitin Carboxyl-Terminal Hydrolase 8;

NCIt synonyms : USP8; Ubiquitin Isopeptidase Y; Deubiquitinating Enzyme HUMORF8; Deubiquitinating Enzyme 8; Ubiquitin-Specific Processing Protease 8; Ubiquitin Thiolesterase 8; EC 3.4.19.12; Ubiquitin Specific Protease-8; hUBPy; Ubiquitin Specific Protease 8;

NCIt definition : Ubiquitin carboxyl-terminal hydrolase 8 (1118 aa, 128 kDa) is encoded by the human USP8 gene. This protein plays a role in both protein deubiquitination and the inhibition of protein degradation.;

Details

Origin ID

C21440;

UMLS CUI

C1447339;

OMIM relation
- Ubiquitin-specific protease 8 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- USP8 protein, human [MeSH concept]
- USP8 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
- USP8 Gene [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitin C-Terminal Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- ERBB2/ERBB3 Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Internalization Pathway for Epidermal Growth Factor Receptor [NCIt concept]
gene_product_malfunction_associated_with_disease
- Myeloproliferative Neoplasm [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- Deubiquitination [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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