Ubiquitin Carboxyl-Terminal Hydrolase 22

Preferred Label : Ubiquitin Carboxyl-Terminal Hydrolase 22;

NCIt synonyms : Ubiquitin Specific Protease 22; Ubiquitin-Specific Processing Protease 22; Ubiquitin Specific Peptidase 3-Like; EC 3.4.19.12; Ubiquitin Thioesterase 22; Ubiquitin-Specific Protease 22; Ubiquitin-Specific-Processing Protease 22; Ubiquitin Thiolesterase 22; Ubiquitin Specific Peptidase 22; Deubiquitinating Enzyme 22; USP22;

NCIt definition : Ubiquitin carboxyl-terminal hydrolase 22 (525 aa, 60 kDa) is encoded by the human USP22 gene. This protein plays a role in the deubiquitination of histones H2A and H2B.;

NCIt note : Ubiquitin carboxyl-terminal hydrolase 22 is part of the transcription regulatory histone acetylation (HAT) complex SAGA. (UniProt);

Details

Origin ID

C132058;

UMLS CUI

C2352015;

Automatic exact mappings (from CISMeF team)
- Ubiquitin-specific protease 22 [OMIM gene]
- ubiquitin specific peptidase 22 [HGNC gene]
OMIM relation
- Ubiquitin-specific protease 22 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Usp22 protein, human [MeSH Supplementary Concept]
- Usp22 protein, human [MeSH concept]
gene_encodes_gene_product
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
- USP22 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitin C-Terminal Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Deubiquitination [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]
- Transcriptional Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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