Ubiquitin Carboxyl-Terminal Hydrolase 46

Preferred Label : Ubiquitin Carboxyl-Terminal Hydrolase 46;

NCIt synonyms : Ubiquitin Specific Protease 46; EC 3.4.19.12; USP46; Ubiquitin-Specific Peptidase 46; Ubiquitin Thioesterase 46; Ubiquitin-Specific Protease 46; Ubiquitin-Specific-Processing Protease 46; Ubiquitin Thiolesterase 46; Ubiquitin Specific Peptidase 46; Deubiquitinating Enzyme 46;

NCIt definition : Ubiquitin carboxyl-terminal hydrolase 46 (366 aa, 42 kDa) is encoded by the human USP46 gene. This protein plays a role in the regulation of glutamate-dependent responses and protein deubiquitination.;

NCIt note : Ubiquitin carboxyl-terminal hydrolase 46 activity may play a role in the proliferation of cells transformed by high-risk strains of HPV. (Molecular Cell, 2018; 72:823-835.);

NCI Metathesaurus CUI : CL950895;

Details

Origin ID

C158826;

UMLS CUI

C5202911;

Automatic exact mappings (from CISMeF team)
- Ubiquitin-specific peptidase 46 [OMIM gene]
- ubiquitin specific peptidase 46 [HGNC gene]
OMIM relation
- Ubiquitin-specific peptidase 46 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
- USP46 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Synapse [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitin C-Terminal Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Deubiquitination [NCIt concept]
- Hydrolysis [NCIt concept]
- Neuronal Transmission [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients