Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1

Preferred Label : Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1;

NCIt synonyms : Neuron Cytoplasmic Protein 9.5; EC 3.4.19.12; PGP9.5; Ubiquitin Thioesterase L1; UCH-L1; PGP 9.5; UCHL1;

NCIt definition : Ubiquitin carboxyl-terminal hydrolase isozyme L1 (223 aa, 25 kDa) is encoded by the human UCHL1 gene. This protein plays a role in ubiquitin metabolism.;

NCIt note : The ubiquitin carboxyl-terminal hydrolase isozyme L1 homodimer may have ATP-independent ubiquitin ligase activity. (UniProt);

Details

Origin ID

C105388;

UMLS CUI

C1436157;

OMIM relation
- Ubiquitin carboxyl-terminal esterase l1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- UCHL1 protein, human [MeSH concept]
- UCHL1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
- UCHL1 Gene [NCIt concept]
gene_product_has_biochemical_function
- Endopeptidase [NCIt concept]
- Ubiquitin C-Terminal Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alpha-Synuclein Signaling Pathway [NCIt concept]
- Parkinson's Disease Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Deubiquitination [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients