Ubiquitin Carboxyl-Terminal Hydrolase 28

Preferred Label : Ubiquitin Carboxyl-Terminal Hydrolase 28;

NCIt synonyms : EC 3.4.19.12; Ubiquitin Thioesterase 28; Ubiquitin-Specific-Processing Protease 28; Deubiquitinating Enzyme 28; USP28;

NCIt definition : Ubiquitin carboxyl-terminal hydrolase 28 (1077 aa, 122 kDa) is encoded by the human USP28 gene. This protein plays a role in both protein deubiquitination and cellular responses to DNA damage.;

Details

Origin ID

C124091;

UMLS CUI

C1100344;

OMIM relation
- Ubiquitin-specific protease 28 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- USP28 protein, human [MeSH Supplementary Concept]
- USP28 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
- USP28 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitin C-Terminal Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Checkpoint [NCIt concept]
- Cell Proliferation [NCIt concept]
- Deubiquitination [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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