NCIt definition : An inhibitor of the 19S proteasome-specific deubiquitylating enzymes (DUBs) USP14
and UCHL5, with apoptosis-inducing and antineoplastic activities. Upon administration,
VLX1570 specifically binds to both USP14 and UCHL5, thereby blocking their deubiquitylating
activity. This blocks the ubiquitin proteasome degradation pathway, prevents the degradation
of defective proteins, and leads to an accumulation of poly-ubiquitylated proteins.
This induces the unfolded protein response (UPR) and results in both the induction
of tumor cell apoptosis and the inhibition of tumor cell growth. USP14 and UCHL5,
overexpressed in various tumor cell types, play a key role in the correct folding
and deubiquitination of proteins.;