Preferred Label : Carbon C 14-labeled Ixazomib;
NCIt synonyms : [14C]-Ixazomib; [14C]-1,4-(R,S)-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic
Acid; [14C]-MLN9708;
NCIt definition : A radioconjugate comprised of the orally available reversible 20S proteasome inhibitor
ixazomib and labeled with the isotope carbon C 14. Upon administration, the ixazomib
moiety hydrolyzes and generates its active form, MLN2238, which inhibits the activity
of the 20S catalytic core subunit of the proteasome. This blocks the targeted proteolysis
normally performed by the proteasome, which results in an accumulation of unwanted
or misfolded proteins. The accumulation of protein may disrupt various cell signaling
pathways, induce apoptosis, and inhibit tumor growth. In addition, this agent targets
tumor suppressor microRNA-33b (miR-33b). Labeling with the radioactive tracer carbon
C 14 allows for evaluation of ixazomib's absorption, distribution, metabolism and
excretion (ADME).;
NCI Metathesaurus CUI : CL453974;
Origin ID : C111566;
UMLS CUI : C3827177;
Semantic type(s)
- concept_is_in_subset
- has_target
