Ixazomib - CISMeF

Preferred Label : Ixazomib;

NCIt synonyms : {(1R)-1-[(2,5-dichlorobenzamido)acetamido]-3-methylbutyl}boronic Acid;

NCIt definition : An active metabolite of MLN9708, a second generation, boron containing peptide proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib binds to and inhibits the 20S catalytic core of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated.;

UNII : 71050168A2;

InChIKey : MXAYKZJJDUDWDS-LBPRGKRZSA-N;

CAS number : 1072833-77-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1072833-77-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MLN-2238;

Chemical formula : C14H19BCl2N2O4;

Codes from synonyms : 289;

Details

Origin ID

C97940;

UMLS CUI

C3273711;

Automatic exact mappings (from CISMeF team)
- Ixazomib [ICD-11 Extension code]
- ixazomib [ATC Code]
CISMeF manual mappings
- Ixazomib (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- ixazomib [MeSH Supplementary Concept]
- ixazomib [MeSH concept]
See also inter- (CISMeF)
- Product containing ixazomib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ixazomib (substance) [SNOMED CT concept]
- Product containing ixazomib (medicinal product) [SNOMED CT concept]
- ixazomib [MeSH Supplementary Concept]
- ixazomib [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Proteasome Function Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Ixazomib Citrate [NCIt concept]
has_target
- Proteasome Subunit Beta Type-5 [NCIt concept]
is_component_of_chemotherapy_regimen
- Icd Regimen [NCIt concept]
is_free_acid_or_base_form_of
- Ixazomib Citrate [NCIt concept]

Keyword's position in hierarchy(ies) :

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