NEDD8 Activating Enzyme

Preferred Label : NEDD8 Activating Enzyme;

NCIt synonyms : NAE; NEDD8 Activating E1 Enzyme; UBA3-NAE1 E1 Enzyme; NEDD8-Activating Enzyme;

NCIt definition : NEDD8 activating enzyme is comprised of NEDD8-activating enzyme E1 regulatory subunit and NEDD8-activating enzyme E1 catalytic subunit. This protein complex modifies the C-terminus of NEDD8 to regulate protein neddylation, ubiquitination and catabolism.;

Details

Origin ID

C95815;

UMLS CUI

C3272370;

Automatic exact mappings (from CISMeF team)
- Neonatal asphyxial encephalopathy (disorder) [SNOMED CT concept]
- Zinc-responsive necrolytic acral erythema [ORDO Disease]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]
has_gene_product_element
- NEDD8-Activating Enzyme E1 Catalytic Subunit [NCIt concept]
- NEDD8-Activating Enzyme E1 Regulatory Subunit [NCIt concept]
is_target
- NEDD8 Activating Enzyme E1 Inhibitor TAS4464 [NCIt concept]
- Pevonedistat [NCIt concept]

Keyword's position in hierarchy(ies) :

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