E3 Ubiquitin-Protein Ligase RNF43

Preferred Label : E3 Ubiquitin-Protein Ligase RNF43;

NCIt synonyms : EC 6.3.2.-, Formerly; RING Finger Protein 124; RING-Type E3 Ubiquitin Transferase RNF43; EC 2.3.2.27; Ring Finger Protein 43;

NCIt definition : E3 ubiquitin-protein ligase RNF43 (783 aa, 86 kDa) is encoded by the human RNF43 gene. This protein is involved in the modulation of both Wnt signaling and protein ubiquitination.;

Details

Origin ID

C107651;

UMLS CUI

C1566185;

Automatic exact mappings (from CISMeF team)
- Ring finger protein 43 [OMIM gene]
- ring finger protein 43 [ORDO Gene]
- ring finger protein 43 [HGNC gene]
OMIM relation
- Ring finger protein 43 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- RNF43 protein, human [MeSH Supplementary Concept]
- RNF43 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- RNF43 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_gene_product_variant
- RNF43 NP_060233.3:p.A169T [NCIt concept]
- RNF43 NP_060233.3:p.D140E [NCIt concept]
- RNF43 NP_060233.3:p.E318D [NCIt concept]
- RNF43 NP_060233.3:p.P154L [NCIt concept]
- RNF43 NP_060233.3:p.R127P [NCIt concept]
- RNF43 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction Inhibition [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]
is_target
- Anti-RNF43 Antibody-drug Conjugate SC-006 [NCIt concept]

Keyword's position in hierarchy(ies) :

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