Preferred Label : Anti-RNF43 Antibody-drug Conjugate SC-006;
NCIt synonyms : ADC SC-006; Anti-RNF43 ADC SC-006;
NCIt related terms : SC-006;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) ring finger protein 43 (RNF43), linked to a DNA
crosslinking pyrrolobenzodiazepine (PBD) dimer, with potential antineoplastic activity.
Upon intravenous administration, the monoclonal antibody moiety of anti-RNF43 ADC
SC-006 targets and binds to RNF43 expressed on tumor cells. Upon binding and internalization,
the cytotoxic PBD moiety is released and forms highly cytotoxic DNA interstrand cross-links,
thereby blocking cell division and killing RNF43-expressing cancer cells. RNF43, a
single-span transmembrane E3 ubiquitin ligase, is overexpressed by certain tumor cell
types and a negative regulator of the Wnt signaling pathway.;
UNII : 293BGU7HL8;
Molecule name : SC 006; SC-006;
NCI Metathesaurus CUI : CL524579;
Origin ID : C136779;
UMLS CUI : C4526974;
Semantic type(s)
- concept_is_in_subset
- has_target
