" /> AMFR wt Allele - CISMeF





Preferred Label : AMFR wt Allele;

NCIt synonyms : AMF Receptor Gene; RNF45 Gene; Autocrine Motility Factor Receptor, E3 Ubiquitin Protein Ligase wt Allele; GP78 Gene; Autocrine Motility Factor Receptor Gene;

NCIt definition : Human AMFR wild-type allele is located within 16q21 and is approximately 64 kb in length. This allele, which encodes E3 ubiquitin-protein ligase AMFR protein, plays a role in cellular motility.;

NCIt note : The AMFR Gene at 16q21 encodes Autocrine Mobility Factor Receptor, which is a glycosylated transmembrane protein and a specific receptor for autocrine motility factor. Autocrine Mobility Factor is a tumor motility-stimulating protein secreted by tumor cells and is localized to the leading and trailing edges of carcinoma balder cells. The level of expression in gastric cancer is associated with the pathologic stage and grade of tumor penetration. Positive AMFR expression is significantly associated with poor prognosis. Two transcript variants encoding different isoforms have been found for this gene.;

GenBank Accession Number : NM_138958;

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12/05/2024


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