E3 Ubiquitin-Protein Ligase DTX1

Preferred Label : E3 Ubiquitin-Protein Ligase DTX1;

NCIt synonyms : Deltex-1; Deltex Protein 1; DTX1 Protein; DTX1; hDx-1; Deltex1; hDTX1; Protein Deltex-1; Deltex Homolog 1; EC 6.3.2.-, Formerly; Deltex Homolog-1 Protein; EC 2.3.2.27;

NCIt definition : E3 ubiquitin-protein ligase DTX1 (620 aa, 67 kDa) is encoded by the human DTX1 gene. This protein is involved in the regulation of Notch-mediated signaling and protein ubiquitination.;

NCIt note : The N-terminus of E3 ubiquitin-protein ligase DTX1 directly interacts with the Notch1 ankyrin repeats, which specifically prevents the recruitment of coactivators and limits CSL protein activation below the threshold needed for induction of T-cell fate.;

Details

Origin ID

C26143;

UMLS CUI

C3712409;

OMIM relation
- Deltex e3 ubiquitin ligase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- DTX1 protein, human [MeSH Supplementary Concept]
- DTX1 protein, human [MeSH concept]
gene_encodes_gene_product
- DTX1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- T-Lymphocyte [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Notch Signaling Pathway [NCIt concept]
- Presenilin Action in Notch and Wnt Signaling Pathways [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Protein-Protein Interaction [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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