NCIt synonyms : RNF106; Ubiquitin-Like With PHD and Ring Finger Domains 1 wt Allele; FLJ21925; Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 Gene; Np95; ICBP90; hUHRF1; hNP95; huNp95;
NCIt definition : Human UHRF1 wild-type allele is located in the vicinity of 19p13.3 and is approximately
59 kb in length. This allele, which encodes E3 ubiquitin-protein ligase UHRF1 protein,
plays a role in both protein ubiquitination and epigenetic silencing of gene transcription.
Aberrant expression of the gene is associated with many neoplastic diseases.;
NCIt note : Aberrant overexpression of the UHRF1 gene may be associated with genomic instablility
in hepatocellular carcinoma and other cancers. (Cancer Cell, 2014; 25:196-209.);