UHRF1 wt Allele

Preferred Label : UHRF1 wt Allele;

NCIt synonyms : RNF106; Ubiquitin-Like With PHD and Ring Finger Domains 1 wt Allele; FLJ21925; Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 Gene; Np95; ICBP90; hUHRF1; hNP95; huNp95;

NCIt definition : Human UHRF1 wild-type allele is located in the vicinity of 19p13.3 and is approximately 59 kb in length. This allele, which encodes E3 ubiquitin-protein ligase UHRF1 protein, plays a role in both protein ubiquitination and epigenetic silencing of gene transcription. Aberrant expression of the gene is associated with many neoplastic diseases.;

NCIt note : Aberrant overexpression of the UHRF1 gene may be associated with genomic instablility in hepatocellular carcinoma and other cancers. (Cancer Cell, 2014; 25:196-209.);

GenBank Accession Number : AF129507;

Détails

Origin ID

C115278;

UMLS CUI

C3890775;

Automatic exact mappings (from CISMeF team)
- Ubiquitin-like protein containing phd and ring finger domains 1 [OMIM gene]
OMIM relation
- Ubiquitin-like protein containing phd and ring finger domains 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 19p13.3 [NCIt concept]
gene_plays_role_in_process
- Chromatin Remodeling [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Methylation Regulation [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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