" /> BIRC6 wt Allele - CISMeF





Preferred Label : BIRC6 wt Allele;

NCIt synonyms : KIAA1289; Baculoviral IAP Repeat-Containing 6 (Apollon) wt Allele; Baculoviral IAP Repeat-Containing 6 Gene; Baculoviral IAP Repeat-Containing Protein 6 Gene; Apollon Gene;

NCIt definition : Human BIRC6 wild-type allele is located within 2p22-p21 and is approximately 261 kb in length. This allele, which encodes baculoviral IAP repeat-containing protein 6, is involved in apoptotic inhibition by ubiquitination regulation.;

NCIt note : The BIRC6 gene is a member of the IAP (inhibitors of apoptosis proteins) family and the ubiquitin-conjugating enzyme family. It is ubiquitously expressed as a 15-kb transcript. The protein encoded by the BIRC6 gene is expressed as a 530-kD protein in gliomas and ovarian cancers. BIRC6 may protect cancer cells from undergoing apoptosis and resist to apoptosis in the presence of anticancer drugs. BIRC6 contains a 70-amino acid cysteine- and histidine-rich baculovirus IAP repeat (BIR) and a zinc-binding RING finger.;

GenBank Accession Number : NM_016252;

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12/05/2024


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