" /> BIRC7 wt Allele - CISMeF





Preferred Label : BIRC7 wt Allele;

NCIt synonyms : MLIAP; KIAP; Baculoviral IAP Repeat-Containing 7 Gene; ML-IAP; Baculoviral IAP Repeat-Containing 7 (Livin) wt Allele; LIVIN; Baculoviral IAP Repeat-Containing Protein 7 Gene;

NCIt definition : Human BIRC7 wild-type allele is located in the vicinity of 20q13.3 and is approximately 5 kb in length. This allele, which encodes baculoviral IAP repeat-containing protein 7, plays a role in anti-apoptotic processes.;

NCIt note : BIRC7 has pleiotropic effects on apoptosis induced by various stimuli. BIRC7's anti-apoptotic activity is achieved by two separate mechanisms: one requiring TAK1-dependent JNK1 activation and the second involving caspase inhibition. Upon receipt of a death stimulus, SMAC is processed to its active form and interacts with the BIR (baculovirus IAP repeat) domain of BIRC7 to abrogate the ability of BIRC7 to inhibit apoptosis. Two splicing variants, alpha and beta, have different biological properties and tissue distribution pattern though both have a significant antiapoptotic activity. The protein encoded by the BIRC7 gene is a potent anti-cell death protein and caspase inhibitor.;

GenBank Accession Number : NM_022161;

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31/05/2025


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