E3 Ubiquitin-Protein Transferase

Preferred Label : E3 Ubiquitin-Protein Transferase;

NCIt synonyms : E3 Ubiquitin-Protein Ligase; E3 Ubiquitin Ligase; E3 Ubiquitin Transferase;

NCIt definition : An ATP-dependent aminoacyltransferase that catalyzes the third step in the ubiquitination reaction via the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to lysine residues found in the final substrate protein.;

NCIt note : The IUBMB has recategorized E3 ubiquitin-protein ligases as transferases (EC 2); specifically aminoacyltransferases (EC 2.3.2.-). There are at several categories of E3 enzymes based on the structure of the active site including: HECT-type (EC 2.3.2.26), RING-type (EC 2.3.2.27), RING-type (cysteine targeting) (EC 2.3.2.36), RBR-type (EC 2.3.2.31) and RCR-type (EC 2.3.2.33).;

NCI Metathesaurus CUI : CL449066;

Détails

Origin ID

C21254;

UMLS CUI

C0077678;

Automatic exact mappings (from CISMeF team)
- parkin RBR E3 ubiquitin protein ligase [HGNC gene]
- parkin RBR E3 ubiquitin protein ligase [ORDO Gene]
Biochemical function of gene products
- BRCA1-Associated RING Domain Protein 1 [NCIt concept]
Currated CISMeF NLP mapping
- Ubiquitin-Protein ligases [MeSH concept]
- ubiquitin-protein ligases [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Ubiquitin--protein ligase (substance) [SNOMED CT concept]
- Ubiquitin-Protein ligases [MeSH concept]
- ubiquitin-protein ligases [MeSH Descriptor]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]
has_gene_product_element
- Cullin-2 [NCIt concept]
- Cullin-5 [NCIt concept]
- Von Hippel-Lindau Disease Tumor Suppressor [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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