" /> E3 Ubiquitin-Protein Transferase - CISMeF





Preferred Label : E3 Ubiquitin-Protein Transferase;

NCIt synonyms : E3 Ubiquitin-Protein Ligase; E3 Ubiquitin Ligase; E3 Ubiquitin Transferase;

NCIt definition : An ATP-dependent aminoacyltransferase that catalyzes the third step in the ubiquitination reaction via the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to lysine residues found in the final substrate protein.;

NCIt note : The IUBMB has recategorized E3 ubiquitin-protein ligases as transferases (EC 2); specifically aminoacyltransferases (EC 2.3.2.-). There are at several categories of E3 enzymes based on the structure of the active site including: HECT-type (EC 2.3.2.26), RING-type (EC 2.3.2.27), RING-type (cysteine targeting) (EC 2.3.2.36), RBR-type (EC 2.3.2.31) and RCR-type (EC 2.3.2.33).;

NCI Metathesaurus CUI : CL449066;

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Keyword's position in hierarchy(ies) : arborescence

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06/07/2025


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