TNF Receptor-Associated Factor 4

Preferred Label : TNF Receptor-Associated Factor 4;

NCIt synonyms : Malignant 62; MLN62 Protein; Cysteine-Rich Domain Associated With Ring and TRAF Domains; TRAF4; TRAF4 Protein; Tumor Necrosis Receptor-Associated Factor 4A; Cysteine-Rich Domain Associated With RING And Traf Domains Protein 1; TNF Receptor-Associated Factor-4 Protein; Metastatic Lymph Node Gene 62 Protein; Tumor Necrosis Receptor-Associated Factor 4; RING Finger Protein 83; MLN 62;

NCIt definition : TNF receptor-associated factor 4 (470 aa, 54 kDa) is encoded by the human TRAF4 gene. This protein plays a role in the modulation of TNF receptor superfamily-dependent signaling.;

NCIt note : TNF receptor-associated factor 4 has an N-terminal RING-type zinc finger motif, three central cysteine-rich TRAF zinc finger domains, and a C-terminal MATH domain.;

Details

Origin ID

C21163;

UMLS CUI

C1450831;

Automatic exact mappings (from CISMeF team)
- TNF Receptor-Associated factor 4 [MeSH Descriptor]
- TNF Receptor-Associated factor 4 [MeSH concept]
- Tnf receptor-associated factor 4 [OMIM gene]
OMIM relation
- Tnf receptor-associated factor 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TRAF4 protein, human [MeSH concept]
- TRAF4 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- TRAF4 Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cysteine-Rich Domain [NCIt concept]
- Ring Finger Domain [NCIt concept]
- TRAF Domain [NCIt concept]
gene_product_is_element_in_pathway
- Small Cell Lung Cancer Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Breast Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Embryogenesis [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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