E3 SUMO-Protein Ligase NSE2

Preferred Label : E3 SUMO-Protein Ligase NSE2;

NCIt synonyms : MMS21 Homolog; Non-SMC Element 2 Homolog; EC 6.3.2.-, Formerly; SMC5/SMC6 Complex SUMO Ligase NSMCE2; hMMS21; Non-Structural Maintenance Of Chromosomes Element 2 Homolog; E3 SUMO-Protein Transferase NSE2; NSMCE2; EC 2.3.2.-;

NCIt definition : E3 SUMO-protein ligase NSE2 (247 aa, 28 kDa) is encoded by the human NSMCE2 gene. This protein plays a role in DNA double-strand break repair by homologous recombination, the prevention of DNA damage-induced apoptosis, and the sumolyation of protein substrates.;

Détails

Origin ID

C131565;

UMLS CUI

C1612005;

Automatic exact mappings (from CISMeF team)
- NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase [ORDO Gene]
- Nse2 (mms21) homolog, smc5-smc6 complex sumo ligase [OMIM gene]
OMIM relation
- Nse2 (mms21) homolog, smc5-smc6 complex sumo ligase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- NSMCE2 protein, human [MeSH Supplementary Concept]
- NSMCE2 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Ligase Gene [NCIt concept]
- NSMCE2 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
- Telomere [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Mitotic Sister Chromatid Cohesion [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Recombination Repair [NCIt concept]
- Telomere Recombination [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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