Telomere - CISMeF

Preferred Label : Telomere;

NCIt synonyms : Telomeres;

NCIt definition : A stretch of repetitive nucleotide sequences (TTAGGG repeats in humans) found at both ends of each chromatid arm that plays a role in chromosome stability during replication.;

Alternative definition : NCI-GLOSS: The ends of a chromosome. Each time a cell divides, the telomeres lose a small amount of DNA and become shorter. Over time, the chromosomes become damaged and the cells die. In cancer cells the telomeres do not get shorter, and may become longer, as the cells divide.;

Codes from synonyms : CDR0000643091;

Details

Origin ID

C13295;

UMLS CUI

C0085187;

Anatomic structure is physical part of
- Cell [NCIt concept]
- Chromosome [NCIt concept]
Associated anatomy of gene products
- ATP-Dependent DNA Helicase PIF1 [NCIt concept]
- Adrenocortical Dysplasia Protein Homolog [NCIt concept]
- CST Complex Subunit CTC1 [NCIt concept]
- CST Complex Subunit STN1 [NCIt concept]
- E3 SUMO-Protein Ligase NSE2 [NCIt concept]
- Probable Helicase Senataxin [NCIt concept]
- Protection of Telomeres Protein 1 [NCIt concept]
- Shelterin [NCIt concept]
- TERF1-Interacting Nuclear Factor 2 [NCIt concept]
- Telomerase Protein Component 1 [NCIt concept]
- Telomere-Associated Protein RIF1 [NCIt concept]
- Telomeric Repeat-Binding Factor 1 [NCIt concept]
- Telomeric Repeat-Binding Factor 2 [NCIt concept]
- Telomeric Repeat-Binding Factor 2-Interacting Protein 1 [NCIt concept]
- Telomeric Repeat-Containing RNA [NCIt concept]
- Telomeric-Repeat Binding Factor [NCIt concept]
Automatic exact mappings (from CISMeF team)
- chromosome, telomeric region [GO term]
- telomerization [IUPAC Term]
Contains anatomical structure(s)
- C-Circle [NCIt concept]
Currated CISMeF NLP mapping
- Telomere analysis [LOINC component]
- telomer [IUPAC Term]
- telomere [MeSH Descriptor]
- telomere [MeSH concept]
False automatic mappings
- obsolete telomere [GO term]
Semantic type(s)
- Cell Component [UMLS semantic type]
UMLS correspondences (same concept)
- obsolete telomere [GO term]
- telomer [IUPAC Term]
- telomere [MeSH concept]
- telomere [MeSH Descriptor]
is_location_of_biological_process
- Elongation by Telomerase [NCIt concept]
- Telomere Capping [NCIt concept]
- Telomere Length Maintenance [NCIt concept]
- Telomere Maintenance [NCIt concept]
- Telomere Recombination [NCIt concept]

Keyword's position in hierarchy(ies) :

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