Elongation by Telomerase

Preferred Label : Elongation by Telomerase;

NCIt definition : Most telomeres are maintained by telomerase. The enzymatic activity of telomerase lengthens terminal regions of eukaryotic telomeric DNA by RNA-templated addition of repeated DNA sequences to compensate for sequence loss as the cells divide. Telomerase specifically elongates the 3-prime end of a single-stranded overhang region on the G-rich 3-prime strand while the C-rich strand can be filled in by DNA polymerases. (NCI);

Details

Origin ID

C20341;

UMLS CUI

C1516808;

Semantic type(s)
- Genetic Function [UMLS semantic type]
biological_process_has_associated_location
- Telomere [NCIt concept]
biological_process_involves_gene_product
- Double-Strand Break Repair Protein MRE11 [NCIt concept]
- Mitogen-Activated Protein Kinase 15 [NCIt concept]
- Protection of Telomeres Protein 1 [NCIt concept]
biological_process_is_part_of_process
- Cell Survival [NCIt concept]
process_involves_gene
- MAPK15 Gene [NCIt concept]
- MAPK15 wt Allele [NCIt concept]
- MRE11 Gene [NCIt concept]
- MRE11 wt Allele [NCIt concept]
- POT1 Gene [NCIt concept]
- POT1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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