Telomere Length Maintenance

Preferred Label : Telomere Length Maintenance;

NCIt synonyms : Length Maintenance;

NCIt definition : Telomeres in human cancer cells consist of a tandem array of telomeric DNA repeats bound to a specialized telomeric proteins. Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA repair activities threaten the integrity of chromosome ends, and extensive genome instability can arise. Both telomerase and recombination can lengthen telomeres. (from PMID 11850780 and NCI);

Details

Origin ID

C20336;

UMLS CUI

C1515260;

Automatic exact mappings (from CISMeF team)
- telomere homeostasis [MeSH Descriptor]
Currated CISMeF NLP mapping
- telomere length maintenance [MeSH concept]
Semantic type(s)
- Genetic Function [UMLS semantic type]
UMLS correspondences (same concept)
- telomere length maintenance [MeSH concept]
biological_process_has_associated_location
- Telomere [NCIt concept]
biological_process_involves_gene_product
- CST Complex Subunit CTC1 [NCIt concept]
- CST Complex Subunit STN1 [NCIt concept]
- RAD50-Interacting Protein 1 [NCIt concept]
- Regulator of Telomere Elongation Helicase 1 [NCIt concept]
- TERF1-Interacting Nuclear Factor 2 [NCIt concept]
- Telomeric Repeat-Binding Factor 1 [NCIt concept]
- Telomeric Repeat-Binding Factor 2 [NCIt concept]
biological_process_is_part_of_process
- Cell Survival [NCIt concept]
process_involves_gene
- CTC1 Gene [NCIt concept]
- CTC1 wt Allele [NCIt concept]
- RINT1 Gene [NCIt concept]
- RINT1 wt Allele [NCIt concept]
- RTEL1 Gene [NCIt concept]
- RTEL1 wt Allele [NCIt concept]
- STN1 Gene [NCIt concept]
- STN1 wt Allele [NCIt concept]
- TERF1 Gene [NCIt concept]
- TERF1 wt Allele [NCIt concept]
- TERF2 Gene [NCIt concept]
- TERF2 wt Allele [NCIt concept]
- TINF2 Gene [NCIt concept]
- TINF2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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