TERF1-Interacting Nuclear Factor 2

Preferred Label : TERF1-Interacting Nuclear Factor 2;

NCIt synonyms : TINF2; TERF1 (TRF1)-Interacting Nuclear Factor 2; TIN2; TRF1-Interacting Nuclear Protein 2; TRF1-Interacting Nuclear Protein-2;

NCIt definition : TERF1-interacting nuclear factor 2 (451 aa, 50 kDa) is encoded by the human TINF2 gene. This protein plays a role in both the regulation of telomere length and the protection chromosome ends.;

NCIt note : TINF2 binds telomeric DNA-binding-protein (TRF1) and is an essential mediator of TRF1 function.;

Details

Origin ID

C21544;

UMLS CUI

C1456460;

OMIM relation
- Trf1-interacting nuclear factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TINF2 protein, human [MeSH Supplementary Concept]
- TINF2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DNA Repair Gene [NCIt concept]
- TINF2 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Fibroblast [NCIt concept]
- Heart [NCIt concept]
- Kidney [NCIt concept]
- Liver [NCIt concept]
- Lung [NCIt concept]
- Pancreas [NCIt concept]
- Placenta [NCIt concept]
- Striated Muscle Tissue [NCIt concept]
- Uterus [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
- Telomere [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Telomerase Regulation Pathway [NCIt concept]
gene_product_is_physical_part_of
- Shelterin [NCIt concept]
gene_product_malfunction_associated_with_disease
- Mixed Embryonal Carcinoma and Teratoma [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair [NCIt concept]
- Telomere Capping [NCIt concept]
- Telomere Length Maintenance [NCIt concept]

Keyword's position in hierarchy(ies) :

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