Telomeric-Repeat Binding Factor

Preferred Label : Telomeric-Repeat Binding Factor;

NCIt synonyms : TRF Protein;

NCIt definition : Human telomeric-repeat binding factor proteins (TRF) 1 and 2 are involved in the control of telomere dynamics in vivo. Reduced expression of TRF1 and TRF2 mRNAs was observed in human malignant hematopoietic and acute leukemia cell lines. However, expression of TRF1 and TRF2 mRNAs increased during differentiation of malignant hematopoietic cell line when induced artificially. Furthermore, studies from gastrointestinal carcinogenesis suggested that down-regulation of the TRF1 expression in tumor cells may be involved in cell immortalization. Together with hTERT, TRF1 and TRF2 are important regulators of telomerase activity and represent potential targets for cancer therapy.;

Details

Origin ID

C17775;

UMLS CUI

C1336701;

Automatic exact mappings (from CISMeF team)
- telomere-binding proteins [MeSH Descriptor]
Biochemical function of gene products
- Protection of Telomeres Protein 1 [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Telomere [NCIt concept]
gene_product_has_structural_domain_or_motif
- DNA Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Ligand Binding [NCIt concept]
- Telomere Maintenance [NCIt concept]

Keyword's position in hierarchy(ies) :

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