Three Prime Repair Exonuclease 2

Preferred Label : Three Prime Repair Exonuclease 2;

NCIt synonyms : EC 3.1.11.2; 3'-5' Exonuclease TREX2 Long Form; 3'-5' Exonuclease TREX2; TREX2;

NCIt definition : Three prime repair exonuclease 2 (279 aa, 31 kDa) is encoded by the human TREX2 gene. This protein is involved in the excision of 3' mismatched 3' termini from double-stranded DNA.;

NCIt note : The gene encoding three prime repair exonuclease 2 is either overlapping or adjacent to the HAUS7 gene. Most mRNAs that encode HAUS augmin-like complex subunit 7 also include the N-terminal part of TREX2. (UniProt);

Details

Origin ID

C21552;

UMLS CUI

C1432810;

OMIM relation
- 3-prime repair exonuclease 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- TREX2 protein, human [MeSH concept]
- TREX2 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- DNA Repair Gene [NCIt concept]
- TREX2 Gene [NCIt concept]
gene_product_has_biochemical_function
- 3'-5' Exonuclease [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EXO I Motif [NCIt concept]
- EXO II Motif [NCIt concept]
- EXO III Motif [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair [NCIt concept]
- DNA Replication Proofreading [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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