NCIt definition : Cullin Family Genes encode Cullin Family Proteins, which are components of SCF ubiquitin
ligase complexes or E3 ubiquitin ligase complexes with elongin BC complexes and other
factors, involved in ubiquitination and proteasomal degradation of target cell cycle,
signal transduction, and transcription proteins. Cullins may act in these multisubunit
complexes as a scaffold for substrates and ubiquitin-conjugating enzymes and interact
with RBX1, RNF7, CYCE, and/or TIP120A/CAND1. (NCI);
Semantic type(s)