E1 Ubiquitin-Activating Enzyme

Preferred Label : E1 Ubiquitin-Activating Enzyme;

NCIt synonyms : Ubiquitin-Activating Enzyme; EC 6.2.1.45; EC 6.3.2.19, Formerly;

NCIt definition : A ligase that catalyzes the first step in the ubiquitination reaction via the ligation of the C-terminal lysine of ubiquitin to the E1 enzyme in an ATP-dependent reaction.;

NCIt note : The IUBMB has recategorized E2 ubiquitin-conjugating enzymes and E3 ubiquitin-protein ligases as transferases (EC 2), and E1 enzymes have had their designation changed from EC 6.3.2.19 to EC 6.2.1.45. Thus, E1, E2 and E3 enzymes may be considered part of a ubiquitin ligase complex, but only E1 enzymes are categorized as ligases (EC 6).;

Details

Origin ID

C133714;

UMLS CUI

C0163974;

Automatic exact mappings (from CISMeF team)
- Ubiquitin--protein ligase (substance) [SNOMED CT concept]
- Ubiquitin-Activating enzymes [MeSH concept]
- ubiquitin activating enzyme activity [GO term]
- ubiquitin activating enzyme complex [GO term]
- ubiquitin like modifier activating enzyme 6 [HGNC gene]
- ubiquitin like modifier activating enzyme 7 [HGNC gene]
- ubiquitin-activating enzymes [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Ubiquitin-Activating enzymes [MeSH concept]
- ubiquitin-activating enzymes [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Ligase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Ubiquitination [NCIt concept]
is_target
- UAE Inhibitor TAK-243 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients