UAE Inhibitor TAK-243

Preferred Label : UAE Inhibitor TAK-243;

NCIt related terms : TAK-243;

NCIt definition : A small molecule inhibitor of ubiquitin-activating enzyme (UAE), with potential antineoplastic activity. UAE inhibitor TAK-243 binds to and inhibits UAE, which prevents both protein ubiquitination and subsequent protein degradation by the proteasome. This results in an excess of proteins in the cells and may lead to endoplasmic reticulum (ER) stress-mediated apoptosis. This inhibits tumor cell proliferation and survival. UAE, also called ubiquitin E1 enzyme (UBA1; E1), is more active in cancer cells than in normal, healthy cells.;

UNII : V9GGV0YCDI;

InChIKey : KJDAGXLMHXUAGV-DGWLBADLSA-N;

CAS number : 1450833-55-2;

Molecule name : MLN7243; TAK-243; AOB87172;

NCI Metathesaurus CUI : CL471769;

Details

Origin ID

C113788;

UMLS CUI

C4287703;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TAK-243 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- E1 Ubiquitin-Activating Enzyme [NCIt concept]

Keyword's position in hierarchy(ies) :

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