" /> DDB1- and CUL4-Associated Factor 1 - CISMeF





Preferred Label : DDB1- and CUL4-Associated Factor 1;

NCIt synonyms : HIV-1 Vpr-Binding Protein; DDB1 and CUL4 Associated Factor 1; Vpr-Binding Protein; EC 2.7.11.1; DCAF1; Vpr-Interacting Protein; Serine/Threonine-Protein Kinase VPRBP; Protein VPRBP;

NCIt definition : DDB1- and CUL4-associated factor 1 (1507 aa, 169 kDa) is encoded by the human DCAF1 gene. This protein plays a role in both serine/threonine-protein kinase activity and E3 ubiquitin-protein ligase complex substrate recognition.;

NCIt note : DDB1- and CUL4-associated factor 1 binds the HIV-1 protein Vpr. This binding protects Vpr from proteosomal degradation and promotes the ubiquitination and degradation of endogenous proteins, which leads to G2 phase cell cycle arrest. (UniProt); DDB1- and CUL4-associated factor 1 is a component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, specifically the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex. (UniProt); DDB1- and CUL4-associated factor 1 binds to the HIV-2 protein Vpx, which enhances macrophage infectivity of the virus. (UniProt); DDB1- and CUL4-associated factor 1 has atypical serine/threonine-protein kinase activity that specifically phosphorylates the threonine at amino acid position 120 of histone H2A (H2AT120ph). H2AT120ph is associated with repression of gene transcription. (UniProt);

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29/04/2024


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