SUMO-Activating Enzyme Subunit 2

Preferred Label : SUMO-Activating Enzyme Subunit 2;

NCIt synonyms : Anthracycline-Associated Resistance ARX; Ubiquitin-Like-Activating Enzyme E1B; EC 6.3.2.-; SUMO-1 Activating Enzyme Subunit 2; Ubiquitin-Like Activating Enzyme E1B;

NCIt related terms : SAE2; UBA2; Ubiquitin-like 1-activating enzyme E1B;

NCIt definition : SUMO-activating enzyme subunit 2 (640 aa, 71 kDa) is encoded by the human UBA2 gene. This protein plays a role in post-translational protein modification.;

Alternative definition : CDISC: An antigen encoded by the UBA2 gene that regulates post-translational protein modification and sumoylation. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases rheumatoid arthritis, primary biliary cirrhosis and dermatomyositis.;

Details

Origin ID

C101570;

UMLS CUI

C1306952;

OMIM relation
- Ubiquitin-like modifier-activating enzyme 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- UBA2 protein, human [MeSH concept]
- UBA2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Ligase Gene [NCIt concept]
- UBA2 Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Sumoylation Pathway [NCIt concept]
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
gene_product_is_physical_part_of
- SUMO-Activating Enzyme [NCIt concept]
gene_product_plays_role_in_biological_process
- Post-Translational Modification [NCIt concept]

Keyword's position in hierarchy(ies) :

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