SUMO-Activating Enzyme

Preferred Label : SUMO-Activating Enzyme;

NCIt synonyms : SUMO1-Activating Enzyme; SAE;

NCIt definition : SUMO-activating enzyme is comprised of SUMO-activating enzyme subunits 1 (SAE1) and 2 (UBA2). This protein complex modifies the C-terminus of SUMO-1 and transfers the SUMO group to SUMO-conjugating enzyme UBC9. This promotes the SUMOylation of target proteins. Modification with SUMO regulates the localization and stability of the target protein.;

NCI Metathesaurus CUI : CL1648594;

Details

Origin ID

C178574;

UMLS CUI

C4484254;

Automatic exact mappings (from CISMeF team)
- SUMO activating enzyme complex [GO term]
- SUMO-activating enzyme [LOINC component]
- endocrine disruptors [MeSH Descriptor]
- stimulated acoustic emission [Radlex concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- SUMO-activating enzyme [LOINC component]
has_gene_product_element
- SUMO-Activating Enzyme Subunit 1 [NCIt concept]
- SUMO-Activating Enzyme Subunit 2 [NCIt concept]
related_to_genetic_biomarker
- SAE1 Gene [NCIt concept]
- UBA2 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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