SUMO-Activating Enzyme Subunit 1

Preferred Label : SUMO-Activating Enzyme Subunit 1;

NCIt synonyms : Sentrin/SUMO-Activating Protein AOS1; SUMO-1 Activating Enzyme E1 N Subunit; Ubiquitin-Like -Activating Enzyme E1A; SUMO-1 Activating Enzyme Subunit 1;

NCIt related terms : SUA1; Ubiquitin-like 1-activating enzyme E1A; SAE1;

NCIt definition : SUMO-activating enzyme subunit 1 (346 aa, 38 kDa) is encoded by the human SAE1 gene. This protein is involved in the regulation of sumoylation.;

Alternative definition : CDISC: An antigen encoded by the SAE1 gene that regulates post-translational protein modification and sumoylation. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases rheumatoid arthritis, primary biliary cirrhosis and dermatomyositis.;

Details

Origin ID

C101573;

UMLS CUI

C3640145;

Automatic exact mappings (from CISMeF team)
- SUMO-activating enzyme subunit 1 [LOINC component]
- SUMO1 activating enzyme subunit 1 [HGNC gene]
- Sumo1-activating enzyme, subunit 1 [OMIM gene]
OMIM relation
- Sumo1-activating enzyme, subunit 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Ligase Gene [NCIt concept]
- SAE1 Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Endoplasmic Reticulum Degradation Pathway [NCIt concept]
- Sumoylation Pathway [NCIt concept]
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
gene_product_is_physical_part_of
- SUMO-Activating Enzyme [NCIt concept]
gene_product_plays_role_in_biological_process
- Post-Translational Modification [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients