LIM Domain Kinase 2

Preferred Label : LIM Domain Kinase 2;

NCIt synonyms : LIMK2; EC 2.7.11.1; LIMK-2;

NCIt definition : LIM domain kinase 2 (638 aa, 72 kDa) is encoded by the human LIMK2 gene. This protein is involved in the phosphorylation of serines or threonines in protein substrates.;

NCIt note : Isoform LIMK2a is distributed in both the cytoplasm and the nucleus; isoform LIMK2b occurs mainly in the cytoplasm and is rarely translocated to the nucleus. (UniProt); Substrates for LIM domain kinase 2 may include myelin basic protein (MBP) and histones. (UniProt);

Details

Origin ID

C132132;

UMLS CUI

C1430543;

Automatic exact mappings (from CISMeF team)
- LIM domain kinase 2 [HGNC gene]
- Lim domain kinase 2 [OMIM gene]
OMIM relation
- Lim domain kinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- LIMK2 protein, human [MeSH Supplementary Concept]
- LIMK2 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- LIMK2 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- LIM Domain [NCIt concept]
- PDZ Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Axon Guidance Pathway [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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