FGR wt Allele - CISMeF

Preferred Label : FGR wt Allele;

NCIt synonyms : Gardner-Rasheed Feline Sarcoma Viral (V-FGR) Oncogene Homolog wt Allele; SRC2; c-fgr Gene;

NCIt definition : Human FGR wild-type allele is located within 1p36.2-p36.1 and is approximately 23 kb in length. This allele, which encodes proto-oncogene tyrosine-protein kinase FGR protein, is involved in the regulation of outside-in signaling-dependent sustained neutrophil adhesion. Amplification of this gene is associated with the development of hormone-resistant prostate cancer.;

NCIt note : The FGR gene also plays a role in integrin-mediated leukocyte activation.;

GenBank Accession Number : NM_005248;

Details

Origin ID

C51113;

UMLS CUI

C1708019;

OMIM relation
- Fgr protooncogene, src family tyrosine kinase [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 1: 27634715-27622953 [NCIt concept]
gene_in_chromosomal_location
- 1p36.2-p36.1 [NCIt concept]
gene_is_element_in_pathway
- Chemokine Signaling Pathway [NCIt concept]
- GPCR Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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