G Protein-Coupled Receptor Kinase 4

Preferred Label : G Protein-Coupled Receptor Kinase 4;

NCIt synonyms : EC 2.7.1.-; G Protein-Coupled Receptor Kinase 2 (Drosophila)-Like; G Protein-Coupled Receptor Kinase GRK4; G Protein-Dependent Receptor Kinase 4; ITI1; GPRK2L; G Protein-Coupled Receptor Kinase 2-Like; EC 2.7.11.16; G Protein-Coupled Receptor Kinase-2-Like Protein;

NCIt definition : G protein-coupled receptor kinase 4 (578 aa, 67 kDa) is encoded by the human GRK4 gene. This protein is involved in the phosphorylation of G protein-coupled receptors.;

NCIt note : Four isoforms have been described for the G protein-coupled receptor kinase 4. Only GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin. (UniProt);

Details

Origin ID

C26232;

UMLS CUI

C1333735;

OMIM relation
- G protein-coupled receptor kinase 4 [OMIM gene]
See also inter- (CISMeF)
- thymidine kinase 2 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- GRK4 protein, human [MeSH Supplementary Concept]
- GRK4 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- G Protein-Coupled Receptor Kinase Gene [NCIt concept]
- GRK4 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- RGS Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Attenuation of GPCR Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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