Bifunctional UDP-N-Acetylglucosamine 2-Epimerase/N-Acetylmannosamine Kinase

Preferred Label : Bifunctional UDP-N-Acetylglucosamine 2-Epimerase/N-Acetylmannosamine Kinase;

NCIt synonyms : UDP-N-Acetylglucosamine 2-Epimerase/N-Acetylmannosamine Kinase; EC 3.2.1.183/EC 2.7.1.60; UDP-N-Acetylglucosamine-2-Epimerase/N-Acetylmannosamine Kinase; GNE; UDP-GlcNAc-2-Epimerase/ManAc Kinase;

NCIt definition : Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (722 aa, 79 kDa) is encoded by the human GNE gene. This protein is involved in both the hydrolysis of UDP-N-acetyl-alpha-D-glucosamine yielding N-acetyl-D-mannosamine and the phosphorylation of N-acyl-D-mannosamine yielding N-acyl-D-mannosamine 6-phosphate.;

NCIt note : Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase activity is dependent on oligomerization; monomers are inactive, dimers catalyze the phosphorylation of N-acetylmannosamine and hexamers possess both epimerase and kinase activities. (UniProt);

Details

Origin ID

C201700;

OMIM relation
- Udp-n-acetylglucosamine 2-epimerase/n-acetylmannosamine kinase [OMIM gene]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- GNE Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Amino and Nucleotide Sugars Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Biosynthetic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Lipid Metabolic Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Post-Translational Modification [NCIt concept]

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