Palmitoyltransferase ZDHHC20

Preferred Label : Palmitoyltransferase ZDHHC20;

NCIt synonyms : DHHC Domain-Containing Cysteine-Rich Protein 20; ZDHHC20; Zinc Finger DHHC-Type Containing 20; DHHC20; EC 2.3.1.225; Zinc Finger DHHC-Type Palmitoyltransferase 20; Acyltransferase ZDHHC20; Zinc Finger DHHC Domain-Containing Protein 20;

NCIt definition : Palmitoyltransferase ZDHHC20 (365 aa, 42 kDa) is encoded by the human ZDHHC20 gene. This protein is involved in cysteine palmitoylation.;

NCIt note : Palmitoyltransferase ZDHHC20 has preference for acyl-CoA with C16 fatty acid chains and can also utilize acyl-CoA with C14 and C18 fatty acid chains. ZDHHC20 catalyzes the transfer of palmitoyl groups to cysteines in proteins including the cytoplasmic C-terminus of EGFR; this modification modulates EGFR internalization and degradation. (UniProt);

Details

Origin ID

C185084;

UMLS CUI

C2935500;

Automatic exact mappings (from CISMeF team)
- Zinc finger dhhc domain-containing protein 20 [OMIM gene]
- zinc finger DHHC-type palmitoyltransferase 20 [HGNC gene]
OMIM relation
- Zinc finger dhhc domain-containing protein 20 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ZDHHC20 protein, human [MeSH Supplementary Concept]
- ZDHHC20 protein, human [MeSH concept]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- ZDHHC20 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Golgi Apparatus [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Metal Binding Site [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Lipid Metabolic Process [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Post-Translational Modification [NCIt concept]

Keyword's position in hierarchy(ies) :

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