Proto-Oncogene DBL

Preferred Label : Proto-Oncogene DBL;

NCIt synonyms : MCF2 p66 Protein; Proto-Oncogene MCF-2; Proto-Oncogene DBL Protein;

NCIt definition : Proto-oncogene DBL (925 aa, 108 kD) is encoded by the human MCF2 gene. This cytoplasmic protein promotes the conversion of certain Rho GTPases from the GDP-bound form to the GTP-bound form, thereby modulating their activity.;

NCIt note : The MCF2 gene encodes four isoforms of this protein, which have varying guanine nucleotide exchange factor (GEF) activities toward the Rho GTPases CDC42, RAC1 and RHOA.;

Details

Origin ID

C45490;

UMLS CUI

C1708810;

OMIM relation
- Mcf.2 cell line-derived transforming sequence [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- MCF2 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_biochemical_function
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- Post-Translational Modification [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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