Protein Disulfide-Isomerase A3

Preferred Label : Protein Disulfide-Isomerase A3;

NCIt synonyms : Protein Disulfide Isomerase-Associated 3; Endoplasmic Reticulum Resident Protein 57; EC 5.3.4.1; ERp57; 58 kDa Glucose-Regulated Protein; 58 kDa Microsomal Protein; ER Protein 57; p58; Endoplasmic Reticulum Resident Protein 60; ERp60; Disulfide Isomerase ER-60; Endoplasmic Reticulum p58; ER Protein 60; PDIA3;

NCIt definition : Protein disulfide-isomerase A3 (505 aa, 57 kDa) is encoded by the human PDIA3 gene. This protein is involved in both the activity of the MHC class I peptide-loading complex and post-translational disulfide bond formation.;

NCIt note : CAUTION - Was originally thought to be phospholipase C-alpha, a phosphatidylinositol 4,5-bisphosphate phosphodiesterase type I enzyme. (UniProt);

Details

Origin ID

C112121;

UMLS CUI

C0251914;

Automatic exact mappings (from CISMeF team)
- Cyclin-dependent kinase 11b [OMIM gene]
- DnaJ heat shock protein family (Hsp40) member C3 [ORDO Gene]
- Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 [OMIM gene]
- Proteasome 26s subunit, non-atpase, 3 [OMIM gene]
- Protein disulfide isomerase, family a, member 3 [OMIM gene]
- calreticulin [MeSH Descriptor]
OMIM relation
- Protein disulfide isomerase, family a, member 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PDIA3 protein, human [MeSH Supplementary Concept]
- PDIA3 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Isomerase Gene [NCIt concept]
- PDIA3 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Chaperone [NCIt concept]
gene_product_has_chemical_classification
- Protein Disulfide-Isomerase Family [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Antigen Processing and Presentation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Presentation [NCIt concept]
- Antigen Processing [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Protein Folding [NCIt concept]

Keyword's position in hierarchy(ies) :

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