NCIt definition : Cytoplasmic proteins of both prokaryotes and eukaryotes that bind to nascent or unfolded
polypeptides and ensure correct folding or transport. Chaperone proteins do not covalently
bind to their targets and do not form part of the finished product. Heat-shock proteins
are an important sub set of chaperones. Three major families are recognised, the chaperonins
(groEL and hsp60), the hsp70 family and the hsp90 family. Outside these major families
are other proteins with similar functions including nucleoplasmin, secB and T-cell
receptor associated protein.;