Heat Shock Protein

Preferred Label : Heat Shock Protein;

NCIt synonyms : Heat Shock Proteins;

NCIt related terms : stress protein; HSP; heat-shock protein;

NCIt definition : A family of highly-conserved proteins that are synthesized in response to hyperthermia (heat shock), hypoxia, or other stresses that appear to increase cellular thermal tolerance and enable cells to recover from stress. Some heat shock proteins may protect other proteins from denaturation, degradation or perform functions essential to cell survival under these conditions.;

Alternative definition : NCI-GLOSS: One of a group of proteins that help protect cells from stresses such as heat, cold, and low amounts of oxygen or glucose (sugar). Heat-shock proteins help other proteins function in normal cells and may be present at high levels in cancer cells. Blocking the activity of a heat-shock protein called HSP90 is being studied in the treatment of cancer. Other heat-shock proteins including HSP70 and gp96 are being studied in vaccines to treat cancer.;

Codes from synonyms : CDR0000617666; CDR0000617665; CDR0000617664;

Details

Origin ID

C16672;

UMLS CUI

C0018850;

Automatic exact mappings (from CISMeF team)
- heat-shock proteins, small [MeSH Descriptor]
- spastic paraplegia, hereditary [MeSH Descriptor]
Currated CISMeF NLP mapping
- Heat-Shock proteins [MeSH concept]
- heat-shock proteins [MeSH Descriptor]
False automatic mappings
- Hereditary spastic paraplegia [ORDO Disease]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Heat-Shock proteins [MeSH concept]
- heat-shock proteins [MeSH Descriptor]
gene_product_has_biochemical_function
- Chaperone [NCIt concept]
- Stress-Induced Protein [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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