Heat Shock Protein 90

Preferred Label : Heat Shock Protein 90;

NCIt synonyms : HSP-90; HSP90; Heat Shock Protein-90;

NCIt definition : A family of structurally related proteins that play a role in cell signalling, protein folding and cellular stress responses. The members of this family are approximately 90 kDa.;

NCIt note : The Heat Shock Protein 90 members HSP89-alpha and HSP89-beta are a class of cytoplasmic molecular chaperone homodimers that act in the signal transduction mechanism of steroid receptors and may have ATPase activity. CDC37 and HSP90 associate preferentially with CDK4 not bound to type D cyclins. HSPA8, HSP90A, CXCR4, and GDF5 on monocytes form an activation cluster after LPS ligation and are involved in LPS signal transduction. (OMIM 140571, Swiss-Prot P07900, P08238);

Details

Origin ID

C17766;

UMLS CUI

C0243044;

Biochemical function of gene products
- Endoplasmin [NCIt concept]
- Heat Shock Protein 75 kDa, Mitochondrial [NCIt concept]
- Heat Shock Protein HSP 90-Alpha [NCIt concept]
- Heat Shock Protein HSP 90-Beta [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HSP90 Heat-Shock proteins [MeSH concept]
- hsp90 heat-shock proteins [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Alvespimycin [NCIt concept]
- Alvespimycin Hydrochloride [NCIt concept]
- Geldanamycin Analogue [NCIt concept]
- Herbimycin [NCIt concept]
- Hsp90 Inhibitor BIIB021 [NCIt concept]
- Retaspimycin [NCIt concept]
- Retaspimycin Hydrochloride [NCIt concept]
- Tanespimycin [NCIt concept]
gene_product_has_biochemical_function
- Chaperone [NCIt concept]
- Stress-Induced Protein [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Stress Response [NCIt concept]
- Protein Folding [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
is_chemical_classification_of_gene_product
- Heat Shock Protein 105 kDa [NCIt concept]
- Putative Endoplasmin-Like Protein [NCIt concept]
is_target
- Alvespimycin [NCIt concept]
- Alvespimycin Hydrochloride [NCIt concept]
- Anthracycline Antineoplastic Antibiotic [NCIt concept]
- Gamitrinib [NCIt concept]
- Ganetespib [NCIt concept]
- HSP90 Peptide Vaccine AST-021p [NCIt concept]
- Hsp90 Antagonist KW-2478 [NCIt concept]
- Hsp90 Inhibitor AB-010 [NCIt concept]
- Hsp90 Inhibitor BIIB021 [NCIt concept]
- Hsp90 Inhibitor BIIB028 [NCIt concept]
- Hsp90 Inhibitor DS-2248 [NCIt concept]
- Hsp90 Inhibitor Debio 0932 [NCIt concept]
- Hsp90 Inhibitor HSP990 [NCIt concept]
- Hsp90 Inhibitor LAM-003 [NCIt concept]
- Hsp90 Inhibitor LAM-003A [NCIt concept]
- Hsp90 Inhibitor MPT0B640 [NCIt concept]
- Hsp90 Inhibitor NVP-BEP800 [NCIt concept]
- Hsp90 Inhibitor SNX-5422 Mesylate [NCIt concept]
- Hsp90 Inhibitor SNX-5542 Mesylate [NCIt concept]
- Hsp90 Inhibitor TQB3474 [NCIt concept]
- Hsp90 Inhibitor XL888 [NCIt concept]
- Hsp90-targeted Photosensitizer HS-201 [NCIt concept]
- Iodine I 124 Icapamespib [NCIt concept]
- Iodine I 124-labeled Hsp90 Inhibitor PUH71 [NCIt concept]
- Locnartecan [NCIt concept]
- Luminespib [NCIt concept]
- Luminespib Mesylate [NCIt concept]
- Near Infrared Imaging Agent HS-196 [NCIt concept]
- Onalespib [NCIt concept]
- Onalespib Lactate [NCIt concept]
- Oral Hsp90 Inhibitor IPI-493 [NCIt concept]
- Retaspimycin Hydrochloride [NCIt concept]
- Tanespimycin [NCIt concept]
- Zelavespib [NCIt concept]

Keyword's position in hierarchy(ies) :

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